(Pyrroloquinoline quinone)

About PQQ

An organic molecule naturally occurring in the food supply, PQQ is the first new vitamin discovered since 1948. It supports the health and proliferation of mitochondria, which generate the energy cells need to function efficiently.* Because the degradation of mitochondria is a key contributing factor to physiological aging in humans, PQQ may:

  • Slow the aging process*
  • Increase energy levels*
  • Improve cognitive function*[1],[2]
  • Alleviate occasional stress and sleeplessness*[3]

Double-blind, placebo-controlled human studies have found PQQ improves spatial awareness, short-term memory and concentration.*

BioPQQ has been used in all of the human clinical studies on PQQ published to date and is the only natural NDI-accepted PQQ on the market. In 2013, BioPQQ won the Engredea Editors’ Choice Award for Ingredient with the Best Science.

Mechanism of Action

Research has shown PQQ:

  • Affects cell-signaling pathways involved in cell growth, differentiation and survival*[4]
  • Protects existing mitochondria from damage*[5]
  • Helps generate new mitochondria*[6],[7]
  • Protect nerve cells*[8]


PQQ is a safe, naturally occurring essential nutrient found in foods such as kiwi, green peppers, potatoes, tofu and green tea. BioPQQ has been the subject of numerous safety studies, including acute toxicity and genotoxicity studies, in both humans and animals.

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[1] Nakano M, et al. FOOD Style 21. 2009;13(7):50-3.
[2] Koikeda T, NereNo M, Masuda K. Med Consult New Remedies. 2011. 48:519-26.
[3] Nakano M, et al. Functional Foods in Health and Disease 2012;2:307-24.
[4] Rucker R, Chowanadisai W, Nakano M. Altern Med Rev. 2009;14(3):268-77.
[5] He K, et al. Biochem Pharmacol. 2003;65:67-74.
[6] Stites T, et al. J Nutr 2006;136:390-6.
[7] Chowanadisai W, et al. J Biol Chem. 2010 Jan 1;285(1):142-52.
[8] Hara H, et al. Neurochem Res. 2007 Mar;32(3):489-95.
*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.