The DDS-1 Strain of L. Acidophilus

The DDS-1 Strain of L. Acidophilus


About The DDS-1 Strain of L. Acidophilus

Lactic acid bacteria are a well-studied group of beneficial bacteria. Lactobacillus acidophilus in particular may be familiar to consumers, as it appears in yogurt and other foods. Discovered by Dr. Khem Shahani at the University of Nebraska, and researched for over 40 years by Dr. Shahani, the DDS-1 strain of Lactobacillus acidophilus is an acid-resistant, bile-resistant, stable strain of L. acidophilus of human origin that has been shown in human, animal, and in vitro research to:

  • Support a healthy balance of beneficial to harmful bacteria*[i],[ii]

  • Produce lactase, which helps lactose-intolerant individuals digest dairy products*[iii]

  • Produce vitamins B6, B12, and folic acid*[iv]

  • Help maintain cholesterol levels already within a normal range*[v]

  • Stimulate the immune system*[vi]

Mechanism of Action

Lactic acid bacteria support a healthy balance of beneficial to harmful bacteria, possibly by lowering the pH of the colon, by adhering to epithelium cells (and therefore crowding out undesirable bacteria) and by competing for food in the large intestine. L. acidophilus may also produce short-chain fatty acids that affect cholesterol synthesis.


L. acidophilus is found naturally in the human gastrointestinal tract and is also frequently consumed in food such as L. acidophilus-enriched milk, yogurt, miso, and tempeh. Human studies have not found any significant side effects from its consumption. However, people taking sulfasalazine for ulcerative colitis should consult with their physicians before taking L. acidophilus, as it may speed up the metabolism of this drug.[vii]

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[i] Reddy GV, et al. Cultured Dairy Prod J. 1983;18(2):15-9.
[ii] Fernandes CF, Shahani KM. Proceedings of Les Laits fermentes: Actualite de le Recherche. 1989; Paris, France. 105-16.
[iii] Fernandes CF, Shahani KM. J Appl Nutr. 1989;41:50-64.
[iv] Reddy KP, Shahani KM, Kulkarni S. J Dairy Sci. 1976;59:191-5.
[v] Danielson AD, et al. J Ani Sci. 1989;67:966-74.
[vi] Rangavajhyala N, Shahani KM. Proc. 20th Anniversary Symposium CERELA (Center for Research on Lactobacilli). 1997; Tucuman, Argentina.
[vii] Lactobacillus acidophilus. University of Maryland Medical Center. Complementary and Alternative Medicine. 2013 May 7.

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.