Proprietary extract of Asparagus officinalis

About ETAS

ETAS is a proprietary ingredient derived from the tough lower portion of asparagus stalks, which has the unique ability to increase the production of heat shock protein 70 (HSP70).* Double-blind, placebo-controlled research has shown ETAS effectively:

  • Increases quality of sleep*[1]
  • Alleviates occasional stress by improving heart rate variability*[2]
  • Raises cognitive performance, reduces fatigue, and improves the stress response*[3],[4],[5]

The extraction process used to create ETAS results in unique hydroxymethyl furfural derivatives — particularly asfural — that are not contained in raw asparagus extract.

Mechanism of Action

ETAS works by increasing the production of HSP70 — an intracellular protein produced naturally by the body when it encounters a stressor, such as extreme heat.*[6]

HSP70 has many beneficial functions. It repairs damaged cells, tips the balance from excitatory cytokines to inhibitory ones and serves as an antioxidant.*[7],[8],[9]  Unfortunately, the heat shock response to stressors of all kinds decreases with age.[10],[11]  Human clinical research has shown that ETAS significantly increases the expression of HSP70 at a dosage of 100 mg elemental ETAS per day.*[12] (The commercially available form of ETAS is 50% elemental ETAS, requiring a dosage of 200 mg per day.)


ETAS is a natural ingredient derived from asparagus, which has been safely consumed as part of the food chain for at least 5,000 years. A 90-day toxicological study found no significant adverse events and confirmed the ingredient’s safety. [13]

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[1] Unpublished study. Hokkaido Information University, Ebetsu, Japan.
[2] Unpublished study. Teikyo Heisei University, Tokyo, Japan.
[3] Unpublished study. Teikyo Heisei University, Tokyo, Japan.
[4] Sakurai T, et al. Nat Prod Commun. 2013;19(11):905-10.
[5] Ogasawara J, et al. Nat Prod Commun. 2014; in press.
[6] Ito T. J Agric Food Chem. 2013;61:9155-9.
[7] Akagi R, et al. Pharmacology. 2013;91(1-2):104-11.
[8] Doeppner TR, et al. J Cereb Blood Flow Metab. 2013 Nov;33:1778-88.
[9] Matsuda M, et al. J Invest Dermatol. 2013 Apr;133(4)919-28.
[10] Njemini R, et al. BMC Immunology. 2011;12:24.
[11] Calderwood SK, Murshid A, Prince T. Gerontology. 2009;55(5);550-8.
[12] Ito T, et al. J. Food Sci. 2014; in press
[13] Ito T, et al. Regul Toxicol and Pharmacol. 2014;68:240-9.
*These statements have not been evaluated by the Food & Drug Administration. This ingredient is not intended to diagnose, treat, cure or prevent any disease.