(Milk Protein)

About MBP

MBP is a component of whey consisting of several different biologically active proteins, including high mobility group-like protein, cystatin C and lactoferrin. Six human clinical studies (including four double-blind placebo-controlled trials) have shown that MBP increases bone mineral density in both young and elderly adults.*

Although milk is high in protein, MBP accounts for only a small fraction of its overall protein content. Therefore, it is not practical to ingest a therapeutic dose of MBP through the consumption of dairy products.

Mechanism of Action

Human clinical research has shown that MBP maintains normal bone metabolism and structure.*[1] It works by:

  • Encouraging healthy bone remodeling.* MBP increases the number of osteoblasts (cells that build bone) and inhibits the activity of osteoclasts (cells that break down bone).*[2],[3]
  • Promoting collagen formation.* Calcium is needed for bone strength, but without collagen, it has no place to attach to the bones. By increasing collagen production, MBP helps calcium adhere to bone.*[4],[5],[6]


MBP is a natural ingredient derived from milk. MBP is FDA GRAS and FOSHU-certified by the Consumer Affairs Agency, Government of Japan. Because MBP may contain trace amount of lactose, caution should be exercised if you are lactose intolerant.

Share this page:


[1] Yamamura J, et al. Biosci. Biotechnol. Biochem. 2002;66(3):702–4.
[2] Toba Y, et al. Biosci. Biotechnol. Biochem. 2001;65(6):1353–7.
[3] Aoe S., et al. Biosci. Biotechnol. Biochem. 2001;65(4):913–8.
[4] Uenishi K, et al. Osteoporos Int. 2007;18:385–90.
[5] Aoyagi Y, et al. Int. Dairy J. 2010;20:724–30.
[6] Aoe S, et al. Osteoporos Int. 2005;16:2123–8.
*These statements have not been evaluated by the Food & Drug Administration. This ingredient is not intended to diagnose, treat, cure or prevent any disease.