Oligonol®

Oligonol®

About Oligonol

Supported by 30 human clinical trials, Oligonol is a patented, low-molecular-weight polyphenolic extract derived from lychee fruit (85%) and green tea (15%) with excellent absorption and multiple anti-aging benefits.*[1],[2] It addresses the three major causes of aging: poor blood circulation, oxidative stress and inflammation.*[3],[4], [5],[6],[7]

Winner of the 2007 Best New Product Award at the 3rd International Conference on Polyphenols and Health (ICPH IFIA/HFE), NutrAward for Best New Ingredient in 2008 and the SupplySide West Scientific Excellence Award in 2011, Oligonol has been clinically shown to:

  • Support healthy post-meal blood glucose and lipid levels*[8],[9]
  • Reduce visceral fat*[10]
  • Lessen skin wrinkles and brown spots*[11],[12]
  • Help decrease fatigue and improve endurance*[13],[14]

Because of its effect on circulation, oxidation and inflammation, Oligonol may also support cardiovascular health.*

Mechanism of Action

The polyphenols from lychee fruit and green tea featured in Oligonol:

  • Increase production of nitric oxide, improving circulation*[15],[16]
  • Neutralize free radicals*[17]
  • Reduce UVB-induced COX-2, to protect cell health*[18]
  • Support healthy levels of inflammatory cytokines*[19]
  • Inhibit the enzyme collagenase, promoting skin health*[20]

Safety

Oligonol is made from lychee fruit and green tea, both of which have a long history of human consumption. Oligonol has been accepted by the FDA as GRAS and it is Kosher and Halal-certified. Multiple studies on humans and animals have confirmed its safety.*[21],[22],[23],[24],[25]

Check out our Sports Nutrition blog post about this ingredient:

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[1] Miura T, et al.  Edited by Bagchi D, et al. Biotechnology in Functional Foods and Nutraceuticals. Chapter 6, 2010.
[2] KulKarni A, et al. Presented at the International Conference and Exhibition on Nutraceuticals and Functional Food. 2009 (INSFF2009).
[3] Bioequivalence study of Oligonol. Report, Amino Up Chemical Company, Ltd. Japan. 2007 Jun 13.
[4] Hackman R, et al. HHPoPo Polyphenols Communications. 2008;2(T5.79)
[5] Aoyagi K. Presented at the 11th Annual Meeting of the Japanese Society for Complementary and Alternative Medicine. 2008 Nov.
[6] Sakurai T, et al. Bisosci Biotechnol Biochem. 2008;72:463-76.
[7] Lee JB, et al.  Nutr Res Practice. 2010; 4(3):203-7.
[8] Nishihira J, et al.  Presented at the 4th International Conference on Polyphenols and Health. 2009.
[9] Tani M, et al. Presented at 15th International Symposium on Atherosclerosis. June 2009 (ICPH2009).
[10] Nishihira J, et al. J Funct Foods. 2009;1(4):341-48.
[11] Tsuboi T, et al. Presented at the 16th AHCC Research Association Meeting. 2008 Aug.
[12] Mackenzie R.  Presented at Experimental Biology Meeting. 2010 Mar.
[13] Ohno H, et al.  Adv Exerc Sports Physiol. 2008; 13(4):93-9.
[14] Shimomura Y, et al. Int J Sports Nutr Exerc Metab. 2010 Jun;20(3):236-44.
[15] Zhang, X, et al. Br J Pharmacol. 2010; 159: 928-938.
[16] Miura T, et al. Biotechnology in Functional Foods and Nutraceuticals. 2010: 91-101.
[17] Aoyagi K, et al. Presented at the 3rd International Conference on Polyphenols and Health. 2007 Nov.
[18] Kundu JK, et al. Photochem Photobiol. 2008;84:399-406.
[19] Lee JB, et al.  Nutr Res Practice. 2010; 4(3):203-7.
[20] Tsuboi T, et al. Presented at the 126th Annual Meeting of the Pharmaceutical Society of Japan. 2006 Mar.
[21] Thirunavukkarasu M, et al. Toxicol Mech Methods. 2012; 22(7):555-9.
[22] Fujii H, et al. Food Chem Toxicol. 2008;46:3553-62.
[23] Spierings E, et al. Unpublished study.
[24] Oligonol Unpublished study. Amino Up Chemical Co., Ltd., Japan. 2006 Jul 20.  
[25] Kitadate K, et al. Regul Toxicol Pharmacol. 2014; 68: 140-146.
*These statements have not been evaluated by the Food & Drug Administration. This ingredient is not intended to diagnose, treat, cure or prevent any disease.