Pumpkin Seed Extract Plus High-Genistein Soy Isoflavones for Healthy Bladder Control*
Nearly one-third of women aged 30 to 60 confront bladder control challenges.*[i] This difficulty can cause social and emotional discomfort, thereby decreasing quality of life. Pelvigen™ is a unique combination of pumpkin seed extract and high-genistein soy isoflavones formulated to support healthy bladder control.*
An open, prospective, eight-week clinical trial of 82 middle-aged women found that Pelvigen™ supported healthy bladder control, reducing feelings of urgency as well as nighttime trips to the bathroom.*[ii] The women reported a 96.2 percent rate of satisfaction with the supplement and an 85.5 percent improvement in quality of life.*
Mechanism of Action
Pumpkin seed has been shown to have antiandrogenic effects in rats.*[iii] By blocking the conversion of testosterone into dihydrotestosterone, it may strengthen pelvic muscles.*[iv] Pumpkin seed is also thought to increase nitric oxide, which positively affects bladder control.*[v] Genistein, a phyto-nutrient that binds to estrogen receptors, has been shown to support bladder integrity in post-menopausal women by increasing the expression M2 and M3 receptors and enhancing the CaBP-9K gene via ER-alpa.*[vi],[vii]
Soy and pumpkin seeds have been consumed in the cuisines of many cultures for many years. Both ingredients are also widely used in supplements. Pelvigen™ has been tested for safety in human research and was found to be safe and effective, with no side effects reported.[viii]
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[i] Marañon J, et al. Gynecol Endocrinol. 2016;32(S1):182.
[ii] Marañon J, et al. 2016.
[iii] Cho YH, et al. Evid Based Complement Alternat Med. 2014;2014:549721.
[iv] Ho MH, Bhatia NN, Bhasin S. Gynecol. 2004 Oct;16(5):405-9.
[v] El-Mosallamy AE, et al. J Med Food. 2012 Feb;15(2)
[vi] Turgut, A, et al Acta Med Medit. 2014;30:907-16.
[vii] Lee, G. Toxicol Studies. 2004;82:451-7.
[viii] Marañon J, et al. 2016.
*These statements have not been evaluated by the Food & Drug Administration. This ingredient is not intended to diagnose, treat, cure or prevent any disease.