Spray-dried Inactivated Cells of Lactobacillus reuteri

About Pylopass®

Maintaining the integrity of the stomach lining is essential for promoting upper GI health. Unfortunately, this delicate lining is compromised in a great number of people.[i]

Pyloplass® provides a unique solution. It is made from a proprietary strain of Lactobacillus reuteri, which was identified after an extensive, multi-year screening process of 8,000 different food grade strains for its unique ability to “hook and remove™” foreign invaders in the stomach.*

Two human clinical trials of Pyloplass®, utilizing the Urea Breath Test, found it was effective in reducing the amount of carbon dioxide in the breath, providing evidence of a more favorable stomach environment for the person.*[ii] Excess carbon dioxide is an indicator that urea is broken down by the foreign invader (into ammonia and carbon dioxide) in order to create a pH-neutral environment for it to survive. Therefore, a decrease of exhaled carbon dioxide indicates better stomach health.

Unlike probiotics, Pylopass® consists of inactivated cells that do not need temperature controls during shipping and storage. Pylopass® is also effective in the harsh environment of the stomach because its action is based solely on its structure — not the number of colony forming units.

Mechanism of Action

The surface of Pylopass® contains unique adhesive molecules that allow it bind to the harmful invader within the stomach and form a co-aggregrate, which can then be eliminated from the body via the digestive tract, as demonstrated in in vitro research.*[iii]


L. reuteri is native to the human gastrointestinal tract and is also found in various foods, including dairy products and fermented rice noodles. The European Food Safety Association classifies it as having Qualified Presumption of Safety (QPS). Pylopass® is non-allergenic, gluten-free, and non-GMO. Its safety has been confirmed in several human tests, including medically vulnerable populations.[iv],[v],[vi]

Share this page:

[i] Center for Disease Control and Prevention. 1998 July.
[ii] Holz C, et al. Probiotics Antimicro Proteins. 2015 Jun;7(2):91-100.
[iii] Holz C, et al. 2012 July 5. Unpublished paper.
[iv] Wolf BW, et al. Microb Ecol Health D. 1995;8:41-50.
[v] Wolf BW, et al. Food Chem Toxicol. 1998;36(12):1085-94 .
[vi] Karvonen A Casas I, Vasikari T. Clin Nutr. 2001;20(suppl 3):63: abstract 216.  

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.