Sirtmax®

Sirtmax®

About Sirtmax®

Increasingly, scientists who study aging have focused their attention on a group of protective genes called sirtuins, especially SIRT1 (known as “the longevity gene”). SIRT1 “recharges” mitochondria — the “power plants” of the cells — which tend to wind down with age. Therefore, any substance that can enhance the SIRT1 gene pathway is of great interest to anti-aging researchers.

Resveratrol is well-known for this effect. Now, there’s another natural ingredient that works in the same way, but is five times more potent (See graph below): Sirtmax®. Derived from the rhizome of black turmeric (Kaempferia parviflora) and rich in polymethoxyflavonoids, Sirtmax® could be the anti-aging ingredient you’re looking for.

A double-blind, placebo-controlled human study with 27 subjects found that taking 100 mg of Sirtmax® daily for seven weeks[1]:

  • Caused a reduction in body weight*
  • Helped maintain blood sugar levels already within a normal range*
  • Decreased the production of advanced glycation end products (AGES)
  • Showed a trend toward improvement in arterial flexibility*

 

Mechanism of Action

Animal and in vitro research has shown that black turmeric inhibits pancreatic lipase (a fat-digesting enzyme) and glycation, a reaction that can cause oxidative damage.[2],[3] In addition, it has a favorable impact on adipogenesis (fat cell differentiation) and the secretion of adiponectin, which regulates glucose levels.[4]

Safety

Black turmeric is related to both turmeric and ginger. One of the most popular herbal medicines in Thailand and Laos, it has been safely consumed as a revitalizing drink for years. A double-blind, placebo-controlled human study on Sirtmax® found no adverse effects.

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[1] Shimada N, et al. The safety and efficacy of Kamepferia parviflora extract (SIRTMAX®) on healthy volunteers. 2012. Unpublished paper.
[2]Shimada T, et al. Preventive effect of Kaempferia parviflora ethyl acetate extract and its major components polymethoxyflavonoid on metabolic diseases. Fitoterepia. 2011;82:1272-78
[3] Nakata A, et al. Potent SIRT1 enzyme-stimulating and anti-glycation activities of polymethoxyflavonoids from Kaempferia parviflora. Natural Products Communications. 2014;9(9):1291-4.
[4] Horikawa T, et al. Polymethoxyflavonoids from Kaempferia parviflora induce adipogenesis on 3T3-L1 preadipocytes by regulating transcription factors at an early stage of differentiation. Biol Pharm Bull. 2012;35(5):686-92.
 
*These statements have not been evaluated by the Food & Drug Administration. This ingredient is not intended to diagnose, treat, cure or prevent any disease.