Microencapsulated Ferric Pyrophosphate with Superior Bioavailability

About UltraFer

Iron is a trace mineral necessary for building hemoglobin — a protein in red blood cells that carries oxygen to the body’s tissues. Iron deficiency, the leading cause of anemia, is marked by fatigue, trouble focusing, breathlessness, and many other symptoms.

Unfortunately, conventional iron supplements frequently cause unpleasant side effects such as heartburn, stomachache, diarrhea, and constipation. As a result, compliance is low. Another problem with iron supplements is poor absorption. In fact, the absorption rate for standard iron supplements is only 10 to 20 percent.

UtraFer is an innovative, highly bioavailable form of iron that has been shown through in vitro research to increase ferritin levels in intestinal cells three to nine times more than conventional iron formulations — without causing side effects.[1]  

Mechanism of Action

The iron in UltraFer is encased in a liposomal-like complex containing ferric pyrophosphate that is ultradispersed in a sucrester (sucrose ester). The lipid bilayer of the complex is similar in structure and properties to cell membranes, which allows the iron to be easily transported past them.


Iron taken in supplement form is notorious for causing gastro-intestinal distress and, in large doses, can be toxic. Associating a mineral with liposomes is thought to markedly change its pharmacokinetics (how it is absorbed and metabolized) and lower systemic toxicity. The patented technology used to encase the iron in UltraFer prevents it from ever coming into contact with the intestinal mucosa, ensuring maximum tolerability and a total absence of side effects.

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[1] Tarantino G, et al. Blood. 2015;126:4561.